International Review of Ophthalmology ›› 2022, Vol. 46 ›› Issue (1): 5-10.doi: 10.3760/ cma.j.issn.1673-5803.2022.01.002

Previous Articles     Next Articles

Roles of oxidative stress in diabetic retinopathy

Liu Yu1, Li Lele2, Sang Aimin3   

  1. 1 Department of Ophthalmology, Taizhen People's Hospital, Taizhou 225300, China; 2 Department of Ophthalmology, Affiliated 2nd Hospital of Nantong University, Nantong 226000, China; 3Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226000, China
  • Received:2021-04-14 Online:2022-02-22 Published:2022-03-14
  • Contact: Sang Aimin, Email: sangam@ntu.edu.cn E-mail:sangam@ntu.edu.cn
  • Supported by:
    Taizhou People's Hospital Scientific Research Start-up Fund（QDJJ202117）

PDF (PC)

2951

Abstract: Diabetic retinopathy (DR) is not only a common complication of diabetic patients, but also one of the serious microvascular complications. There are many reasons for the occurrence of DR, the exact pathogenesis is still unclear, but oxidative stress has an important relationship with the occurrence and development of DR. Oxidative stress activates DR through advanced glycation end products (AGE) pathway, polyol pathway, hexosamine pathway and protein kinase C (PKC) pathway, generates a large number of reactive oxygen species (ROS), damages retina, leads to oxidative damage of DNA, and finally leads to apoptosis. The increase of oxidative stress level activates cytokines, and cytokines can further up regulate the level of oxidative stress and form a vicious circle. (Int Rev Ophthalmol, 2022, 46: 5-10)

Key words: diabetic retinopathy, oxidative stress, ROS